Cardinals vs. Giants prediction and odds for Tuesday, April 25 (San Fran crushes righties)

The San Francisco Giants shut out the St. Louis Cardinals on Monday, blanking them by a final score of 4-0.

The two teams will face-off in Game 2 of a four-game set on Tuesday night. Jake Woodford (6.05 ERA) will get the start for the Cardinals and he'll face-off against fellow right-handed pitcher, John Brebbia (5.63 ERA).

Let's dive into the odds for the game and then I'll break down why you should bet on the Giants to take the 2-0 series lead.

Cardinals vs. Giants odds, run line, and total

Cardinals vs. Giants prediction and pick

The Cardinals offense falls off a cliff when they have to take on a right-handed pitcher. Against lefties, the Cardinals have the best OPS in the Majors at .924, but that drops down to .739 against righties.

The complete opposite is true for the Giants, who go from 29th in OPS against lefties at .597, to 3rd in OPS against right-handed arms at .805.

With tonight being a battle of two right-handed starters, that gives the Giants a big time matchup advantage.

The main problem with the Giants is their bullpen, which ranks 27th in bullpen ERA at 5.29. But, the offensive advantage for the Giants is enough to justify a bet on them at home at pick'em odds.

Give me San Francisco at -110.

Game odds refresh periodically and are subject to change.